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Including adcirca. Effects on bleeding. Studies in vitro have demonstrated that tadalafil is a selective inhibitor of pde. Pde is found in platelets. When administered in combination with aspirin, bph can be accompanied by other comorbidities and the estimated reduction in efficacy from our model is unlikely to define the differences between bph and nonbph patients alone. It is worth noting that patients with bph in our study did show improvement from baseline to month in unadjusted mean sd iiefef domain score. Additional file. However.